Video Gallery

3D Imaging Seminar Series

Listen in as we share how to get the most out of the enormous amount of data extracted from these experiments.

Key takeaways include:

• an end-to-end workflow to streamline the Cell Painting assay
• a high-content solution to automate sample preparation and imaging
• how to simplify results from complex datasets using advanced cloud-based analytics with StratoMineR

New standard in organoid culture and image-based analyses

The need to reduce drug attrition rates and the use of animal experimentation has led to the development of more complex in vitro models such as organoids. While organoids hold great potential for drug toxicity and efficacy assessment, their complexity introduces challenges that can hinder their wider use in existing drug development workflows.

Join the experts as they discuss how to standardize and optimize your 3D cultures to fully automate your organoid workflows and deliver robust, reproducible results.

Key takeaways include:

• How to overcome the complexities of organoid imaging and assays
• How to leverage label-free imaging and AI-based analysis for phenotypic profiling
• How to screen 3D organoid models with high-content image and analysis

Automate your 3D biology high-throughput workflows

There is a growing need in cell-based assays for drug discovery and disease modeling to closely represent biologically relevant microenvironments. This has led to increased interest in three-dimensional (3D) models for assay development and phenotypic screening as they better represent the complexity of human tissue. However, reliability and scalability challenges associated with 3D model development impacts its widespread adoption.

• How to incorporate automation into your 3D biology workflows to generate phenotypic data from complex models in a high-throughput setting
• How to leverage bioprinting for 3D biology applications such as spheroid and organoid formation, assay performance, and vascularized human tissue
• How to monitor cell responses in real time to increase throughput and reduce variability

Leverage automated, end-to-end workflows to enable complex organoid assays

3D organoids are becoming popular in drug discovery and disease modeling as they better represent biologically relevant microenvironments. However, the protocols for organoid assays are complex and often require labor-intensive monitoring by highly trained specialists. In addition, there is a lack of clarity about automation’s contribution to increasing assay throughput, scalability, and workflow reliability, while still reducing overall cost.

Key takeaways include:

• Tools to increase organoid assay throughput and automation
• Analysis approaches to gain more insight into complex systems, disease phenotypes, and compound effects
• Methods to automate cell culture and cell analysis of 3D organoids
• Examples of automated seeding, media exchange, organoid development monitoring, and phenotypic change evaluation

3D Tissue Models Imaging and Automation of Organ-On-A-Chip

In this webinar, Dr Oksana Sirenko from Molecular Devices and Dr Chiwan Chiang from MIMETAS discuss the benefits offered by organ-on-a-chip assays, considerations when imaging these models, and how automated screening systems using these models can be implemented.